Why the study?
Does barodenervation alter cardiovascular responses to acute hypoxia and hypercapnia in conscious rats?
Population
Conscious rats chronically instrumented to monitor systemic hemodynamics
Comparison
Barodenervation vs Intact rats (control)
Design
Preclinical
Key result
Barodenervation in conscious rats eliminated the bradycardia and cardiac output reduction seen with 10% CO2 and caused a marked fall in blood pressure and total peripheral resistance during hypoxia.
Authors
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Baroreflex integrity shapes rat responses to hypercapnia and hypoxia; leaves open human translation and clinical relevance.
Does barodenervation alter cardiovascular responses to acute hypoxia and hypercapnia in conscious rats?
The arterial baroreflex is an important component of the overall cardiovascular responses to both hypercapnic and hypoxic stimuli in the conscious rat.
Walker et al. (1990) studied Cardiovascular responses to hypoxia and hypercapnia. Barodenervation vs. Intact rats was evaluated on Cardiovascular responses (blood pressure, total peripheral resistance, heart rate, cardiac output) to varying inspired levels of O2 and CO2. Barodenervation in conscious rats eliminated the bradycardia and cardiac output reduction seen with 10% CO2 and caused a marked fall in blood pressure and total peripheral resistance during hypoxia.