Ultrastructural studies of pial vascular endothelium following damage resulting in loss of endothelium-dependent relaxation.
Population
7 cats (pial arterioles, 19 vessels examined)
Design
Preclinical
Follow-up
3.5-4 hours
Authors
Discussion
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Member takes
Implication
Minimal trauma may impair cerebral endothelial relaxation without cell death; leaves open relevance to human post-traumatic vasomotor dysfunction.
Structured PICO
P
Population
7 cats (pial arterioles, 19 vessels examined)
I
Intervention
Injury produced by exposing vessels to mercury light in situ in the presence of intravascular sodium fluorescein dye
O
Outcome
Ultrastructural changes in endothelial cells evaluated by electron microscopysurrogate
Minimal degrees of trauma, rather than irreversible cell damage or death, are sufficient to impair endothelium-dependent relaxation in cerebral microvessels.
Cite This Study
Rosenblum et al. (1987) studied this question.