What does this research mean for the field?

Acute severe hypertension causes cerebral arteriolar abnormalities through a mechanism involving a sudden increase in prostaglandin synthesis that leads to the generation of free oxygen radicals. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1981AJP Heart and Circulatory Physiology

Mechanism of cerebral arteriolar abnormalities after acute hypertension

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Why the study?

Does pretreatment with cyclooxygenase inhibitors or free oxygen radical scavengers prevent cerebral arteriolar abnormalities in cats with acute severe hypertension?

Population

Anesthetized cats equipped with a cranial window subjected to acute severe hypertension induced by…

Comparison

Pretreatment with inhibitors of cyclooxygenase… vs Normal animals and untreated hypertensive cats

Design

Preclinical

Authors

HKH. A. KontosVirginia Commonwealth University Medical Center EWE. P. WeiUniversity of Hong Kong WDW. Dalton DietrichCURE International UK

Discussion

Member takes

Implication

Hypothesis-generating for prostaglandin and oxidative pathways in acute hypertensive cerebral injury; human studies needed before any clinical consideration.

Structured PICO

Does pretreatment with cyclooxygenase inhibitors or free oxygen radical scavengers prevent cerebral arteriolar abnormalities in cats with acute severe hypertension?

Population

Anesthetized cats equipped with a cranial window subjected to acute severe hypertension induced by intravenous norepinephrine or angiotensin

Intervention

Pretreatment with inhibitors of cyclooxygenase (indomethacin or AHR-5850) or topical application on the brain surface of scavengers of free oxygen radicals (mannitol or superoxide dismutase)

Comparator

Normal animals and untreated hypertensive cats

Outcome

Cerebral arteriolar abnormalities (prolonged arteriolar vasodilation, reduced responsiveness to arterial hypercapnia/hypocapnia, destructive endothelial lesions, and reduced oxygen consumption)surrogate

Acute severe hypertension causes cerebral arteriolar abnormalities via a mechanism involving increased prostaglandin synthesis and generation of free oxygen radicals.

Cite This Study

Kontos et al. (1981) studied this question.

synapsesocial.com/papers/6a1d756c33e2df9c962f8d72 https://doi.org/10.1152/ajpheart.1981.240.4.h511

Topics

Hypertension management

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Implication

Hypothesis-generating for prostaglandin and oxidative pathways in acute hypertensive cerebral injury; human studies needed before any clinical consideration.

Mechanism of cerebral arteriolar abnormalities after acute hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Mechanism of cerebral arteriolar abnormalities after acute hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider