Population
Rats with experimental hypertension induced by left nephrectomy, deoxycortone acetate implants, and 1% NaCl…
Design
Preclinical
Follow-up
16-18 days
Authors
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These rat model findings remain preclinical; leaves open whether a prenecrotic phase precedes human hypertensive arteriolar necrosis.
This study defines a 'prenecrotic phase' in experimental rat hypertension, identifying early histological and biochemical changes that precede overt arteriolar necrosis.
D. L. Gardner (1963) studied this question.
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