Why the study?
Does induced hypertension increase the size of ischemic infarcts following middle cerebral artery occlusion in cats?
Population
16 cats (8 with induced hypertension via nephrectomy and wrapping the opposite kidney, 8 normotensive)
Comparison
Middle cerebral artery occlusion in the setting… vs Middle cerebral artery occlusion in normotensive…
Design
Preclinical
Authors
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Larger infarcts in hypertensive feline MCA occlusion model; hypothesis-generating for hypertension's role in human stroke severity.
Does induced hypertension increase the size of ischemic infarcts following middle cerebral artery occlusion in cats?
In a feline model, pre-existing hypertension resulted in larger cerebral infarcts following middle cerebral artery occlusion, suggesting hypertension may predispose humans to larger strokes.
Hayakawa et al. (1979) studied this question.
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