Why the study?
Does simvastatin increase coronary vascular endothelial nitric oxide production in conscious dogs?
Population
Conscious mongrel dogs instrumented under general anesthesia
Comparison
Simvastatin 20 mg/kg/day orally for 2 weeks vs Control (baseline)
Design
Preclinical
Follow-up
2 weeks
Authors
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Does not alter clinical statin use; leaves open translation of coronary NO effects to humans.
Does simvastatin increase coronary vascular endothelial nitric oxide production in conscious dogs?
Short-term simvastatin administration in dogs increases coronary endothelial NO production, enhancing NO-dependent coronary vasodilation and regulation of myocardial oxygen consumption.
Mital et al. (2000) studied this question.
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