Preservation of NO production by statins in the treatment of heart failure
Key result
Simvastatin lowered left ventricular end diastolic pressure (18 vs 25 mm Hg, p<0.05) and preserved NO-dependent coronary vasodilation in dogs with pacing-induced heart failure.
Why the study?
Does simvastatin improve NO production and hemodynamics in dogs with pacing-induced heart failure?
Population
Dogs (n=17) instrumented for measurement of coronary blood flow and LVEDP, with pacing-induced heart failure
Comparison
Simvastatin 20 mg/kg/day orally from the 10th… vs Pacing-induced heart failure without simvastatin…
Design
Preclinical
Follow-up
4-5 weeks of pacing
Authors
Discussion
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Member takes
Implication
Does not support simvastatin for HF hemodynamics; leaves open whether NO preservation extends beyond canine pacing models.
Structured PICO
Does simvastatin improve NO production and hemodynamics in dogs with pacing-induced heart failure?
P
Population
17 dogs with pacing-induced heart failure evaluated for the effects of simvastatin over 4 to 5 weeks.
I
Intervention
Simvastatin 20 mg/kg/day orally from the 10th day of pacing
C
Comparator
Pacing-induced heart failure without simvastatin treatment
O
Outcome
Left ventricular end diastolic pressure (LVEDP), NO-dependent coronary vasodilation, nitrite production in coronary microvessels, NO-dependent decrease in myocardial oxygen consumption (MVO2), and eNOS protein levelssurrogate
Main Result
Absolute Event Rate: 18% vs 25%
p-value: p=<0.05
Simvastatin preserves endothelial NO production and bioactivity in a canine model of pacing-induced heart failure, suggesting a potential mechanism for statin benefit in HF.
Cite This Study
Jean‐Noël Trochu (2003) studied Pacing-induced heart failure (n=17). Simvastatin vs. Heart failure without simvastatin was evaluated on Left ventricular end diastolic pressure (LVEDP) at 4 weeks of pacing (p=<0.05). Simvastatin lowered left ventricular end diastolic pressure (18 vs 25 mm Hg, p<0.05) and preserved NO-dependent coronary vasodilation in dogs with pacing-induced heart failure.