August 1, 2003Journal of Applied Physiology
Statin therapy restores sympathovagal balance in experimental heart failure
Key result
Simvastatin beneficially affected autonomic tone in rabbits with pacing-induced chronic heart failure, reversing depressed heart rate variability and total power in a dose-dependent manner.
Why the study?
Does simvastatin improve autonomic balance in rabbits with pacing-induced chronic heart failure?
Population
Rabbits with pacing-induced chronic heart failure (CHF)
Comparison
Simvastatin over a 3-week period vs Normal rabbits and CHF vehicle-treated rabbits
Design
Preclinical
Follow-up
3 weeks
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for statin effects on autonomic tone in HF models; leaves open clinical translation.
Structured PICO
Does simvastatin improve autonomic balance in rabbits with pacing-induced chronic heart failure?
P
Population
Rabbits with pacing-induced chronic heart failure treated over a 3-week period.
I
Intervention
Simvastatin (0.3, 1.5, or 3 mg/kg/day orally) over a 3-week period
C
Comparator
Normal rabbits and CHF vehicle-treated rabbits
O
Outcome
Autonomic balance assessed by measuring heart rate variability, including power spectral analysis (PSA)surrogate
In a rabbit model of pacing-induced heart failure, simvastatin dose-dependently restored autonomic balance by improving depressed heart rate variability.
Cite This Study
Pliquett et al. (2003) studied Chronic heart failure (CHF). Simvastatin vs. Normal and CHF vehicle-treated rabbits was evaluated on Heart rate variability (SD for all intervals). Simvastatin beneficially affected autonomic tone in rabbits with pacing-induced chronic heart failure, reversing depressed heart rate variability and total power in a dose-dependent manner.