Effect of simvastatin in the autonomic system is dependent on the increased gain/sensitivity of the baroreceptors
Why the study?
Does simvastatin improve baroreflex sensitivity and reduce sympathetic activity in spontaneously hypertensive rats?
Population
Male spontaneously hypertensive rats (SHR), n=16
Comparison
Simvastatin 5 mg/kg/day for 7 days vs Control (untreated SHR)
Design
Preclinical
Follow-up
7 days
Authors
Discussion
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Member takes
Implication
No immediate change to hypertension management; leaves open translation of simvastatin effects on baroreflex and sympathetic activity to humans.
Structured PICO
Does simvastatin improve baroreflex sensitivity and reduce sympathetic activity in spontaneously hypertensive rats?
P
Population
Male spontaneously hypertensive rats (SHR), n=16
I
Intervention
Simvastatin 5 mg/kg/day for 7 days
C
Comparator
Control (untreated SHR)
O
Outcome
Baroreflex sensitivity, sympathetic activity, and morphological adaptations in the carotid arteriessurrogate
Simvastatin reduces sympathetic outflow in hypertension by inducing structural changes in carotid arteries and improving baroreflex sensitivity, independent of blood pressure reduction.
Cite This Study
Moreira et al. (2013) studied this question.