Key result
Simvastatin reduced blood pressure and basal renal sympathetic nerve activity in spontaneously hypertensive rats via Ras-mediated activation of PI3K-Akt and ERK1/2-RSK signalling pathways.
Why the study?
Does central administration of simvastatin reduce blood pressure in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHRs)
Comparison
Intracerebroventricular administration of… vs Simvastatin in the presence of specific…
Design
Preclinical
Authors
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Central simvastatin effects in hypertensive rats remain hypothesis-generating; should not alter human hypertension management.
Does central administration of simvastatin reduce blood pressure in spontaneously hypertensive rats?
Simvastatin exerts a central hypotensive effect in spontaneously hypertensive rats via Ras-mediated activation of PI3K-Akt and ERK1/2-RSK pathways leading to eNOS up-regulation.
Cheng et al. (2013) studied Hypertension. Simvastatin vs. Absence of simvastatin or presence of specific inhibitors was evaluated on Blood pressure and renal sympathetic nerve activity. Simvastatin reduced blood pressure and basal renal sympathetic nerve activity in spontaneously hypertensive rats via Ras-mediated activation of PI3K-Akt and ERK1/2-RSK signalling pathways.
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