Key result
Atorvastatin significantly decreased systolic blood pressure and 24-h urinary norepinephrine excretion in stroke-prone spontaneously hypertensive rats, but not in Wistar-Kyoto rats.
Population
Stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats
Design
Preclinical
Follow-up
30 days
Authors
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Does not support clinical use in hypertension; leaves open whether central eNOS effects merit human mechanistic studies.
Atorvastatin decreases blood pressure and sympathetic nervous system activity in stroke-prone spontaneously hypertensive rats, potentially mediated by increased NO production via eNOS upregulation in the brain.
Kishi et al. (2003) studied Hypertension. Atorvastatin was evaluated on Systolic blood pressure, heart rate, urinary norepinephrine excretion, and NOS expression. Atorvastatin significantly decreased systolic blood pressure and 24-h urinary norepinephrine excretion in stroke-prone spontaneously hypertensive rats, but not in Wistar-Kyoto rats.
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