October 1, 2001Hypertension

Overexpression of eNOS in the RVLM Causes Hypotension and Bradycardia Via GABA Release

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Why the study?

Does overexpression of eNOS in the RVLM reduce blood pressure and heart rate in conscious rats?

Population

Conscious rats

Comparison

Adenovirus vectors encoding endothelial NO… vs Adenovirus vectors encoding beta-galactosidase…

Design

Preclinical

Follow-up

10 days

Authors

TKTakuya KishiGeneral Cardiology YHYoshitaka HirookaGeneral Cardiology KSKoji SakaiMeiji University

Discussion

Member takes

Implication

Hypothesis-generating for RVLM eNOS in hypertension; leaves open translation to human therapy.

Structured PICO

Does overexpression of eNOS in the RVLM reduce blood pressure and heart rate in conscious rats?

Population

Conscious rats

Intervention

Adenovirus vectors encoding endothelial NO synthase (AdeNOS) transfected into the bilateral rostral ventrolateral medulla (RVLM)

Comparator

Adenovirus vectors encoding beta-galactosidase (Adbetagal) transfected into the bilateral RVLM

Outcome

Mean arterial blood pressure (MAP) and heart ratesurrogate

Overexpression of eNOS in the RVLM decreases blood pressure, heart rate, and sympathetic nerve activity in conscious rats, likely mediated by increased GABA release.

Cite This Study

Kishi et al. (2001) studied this question.

synapsesocial.com/papers/6a90882af5c79ce9992dbcbd https://doi.org/10.1161/hyp.38.4.896

View Full Paper

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Overexpression of eNOS in the RVLM Causes Hypotension and Bradycardia Via GABA Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Overexpression of eNOS in the RVLM Causes Hypotension and Bradycardia Via GABA Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider