Why the study?
Does overexpression of eNOS in the RVLM improve impaired baroreflex control of heart rate in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto rats (WKY)
Comparison
Transfection of adenovirus vectors encoding eNOS… vs Nontransfected rats
Design
Preclinical
Follow-up
7 days after gene transfer
Authors
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Does not alter hypertension management; extends preclinical baroreflex data and leaves open translational potential.
Does overexpression of eNOS in the RVLM improve impaired baroreflex control of heart rate in stroke-prone spontaneously hypertensive rats?
Overexpression of eNOS in the RVLM improves impaired baroreflex control of heart rate in stroke-prone spontaneously hypertensive rats via a cardiac sympathoinhibitory effect.
Kishi et al. (2003) studied this question.
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