nNOS gene transfer to RVLM improves baroreflex function in rats with chronic heart failure

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Population

Rats with chronic heart failure induced by coronary artery ligation 6-8 weeks prior, and sham-operated rats.

Comparison

Gene transfer of neuronal nitric oxide synthase… vs Recombinant adenovirus expressing…

Design

Preclinical

Follow-up

3 days after gene transfer

Authors

Discussion

Supports nNOS gene transfer to restore baroreflex function in CHF; hypothesis-generating for human translation.

Population

Rats with chronic heart failure (CHF) induced by coronary artery ligation 6-8 weeks prior, and sham-operated rats.

Intervention

Gene transfer of neuronal nitric oxide synthase (nNOS) into the rostral ventrolateral medulla (RVLM) via recombinant adenovirus (Ad.nNOS).

Comparator

Recombinant adenovirus expressing beta-galactosidase (Ad.beta-Gal) transfected into the RVLM.

Outcome

Baroreflex control of heart rate (HR) and renal sympathetic nerve activity (RSNA) assessed 3 days after gene transfer.surrogate

Gene transfer of nNOS into the RVLM improves baroreflex function in a rat model of chronic heart failure.

Wang et al. (2003) studied this question.

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