Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 22, 2007Hypertension

Noradrenergic Cell Specific Gene Transfer With Neuronal Nitric Oxide Synthase Reduces Cardiac Sympathetic Neurotransmission in Hypertensive Rats

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does Ad.PRS-nNOS gene transfer reduce cardiac sympathetic neurotransmission in spontaneously hypertensive rats?

Population

Age-matched male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats

Comparison

Ad.PRS-nNOS (adenovirus encoding neuronal NO… vs Ad.PRS-eGFP

Design

Preclinical

Follow-up

5 days

Authors

DLDan LiGeneral CardiologyLWLijun WangTarim UniversityCLChee-wan LeeBritish Heart Foundation

Discussion

Loading...

Member takes

Overview

Attenuates sympathetic drive in hypertensive rat atria; leaves open translation of nNOS gene transfer to human hypertension therapy.

Structured PICO

Does Ad.PRS-nNOS gene transfer reduce cardiac sympathetic neurotransmission in spontaneously hypertensive rats?

P
Population
Age-matched male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
I
Intervention
Ad.PRS-nNOS (adenovirus encoding neuronal NO synthase with a noradrenergic neuron-specific promoter, 5x10(10) particles) targeted to the right atrial wall by percutaneous injection
C
Comparator
Ad.PRS-eGFP (adenovirus encoding enhanced green fluorescence protein)
O
Outcome
Evoked [(3)H] norepinephrine (NE) release, NOS activity, and cGMP levels measured 5 days after transductionsurrogate

Artificial upregulation of sympathetic nNOS via gene transfer with a noradrenergic promoter restores cGMP levels and attenuates norepinephrine release, offering a potential approach for correcting peripheral sympathetic hyperactivity in hypertension.

Cite This Study

Li et al. (2007) studied this question.

synapsesocial.com/papers/6a7558fbb35e02fb15034711https://doi.org/10.1161/hypertensionaha.107.088591
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renovascular effects of sympathetic cotransmitters ATP and NPY are age-dependent in spontaneoulsy hypertensive rats2005 · 35 citations
  2. 2Modulation of norepinephrine release by ATP-dependent K+-channel activators and inhibitors in guinea-pig and human isolated right atrium1999 · 52 citations
  3. 3Sympathetic Neural Activation in Nondiabetic Metabolic Syndrome and Its Further Augmentation by Hypertension2004 · 211 citations
  4. 4Sympathetic Activity and Cardiovascular Risk Factors in Young Men in the Low, Normal, and High Blood Pressure Ranges2006 · 71 citations
  5. 5Intermittent hypoxia modulates nNOS expression and heart rate response to sympathetic nerve stimulation2001 · 28 citations