June 3, 2009The Journal of PhysiologyOpen Access

Long‐term effect of neuronal nitric oxide synthase over‐expression on cardiac neurotransmission mediated by a lentiviral vector

View Full Paper

Ask AI

Bookmark

Population

Spague-Dawley (SD) rats

Comparison

Lentiviral vector with an elongation factor 1… vs Lentiviral vector driving enhanced green…

Design

Preclinical

Follow-up

4 months

Authors

LWLijun WangTianjin Fourth Central Hospital DLDan LiGeneral Cardiology TDTom DawsonUniversity of Exeter

Discussion

Member takes

Implication

Hypothesis-generating for nNOS-based autonomic modulation in cardiac disease; leaves open translation to humans.

Structured PICO

Population

Spague-Dawley (SD) rats

Intervention

Lentiviral vector with an elongation factor 1 (EF1alpha) promoter driving nNOS expression (Lenti.EF1alpha-nNOS) transferred to the right atrium

Comparator

Lentiviral vector driving enhanced green fluorescent protein (eGFP) expression (Lenti.EF1alpha-eGFP)

Outcome

Acetylcholine (ACh) or noradrenaline (NA) release to field stimulation at 4 months after gene transfersurrogate

Persistent nNOS over-expression mediated by a lentiviral vector enhances cholinergic and inhibits sympathetic neurotransmission in the heart, offering a potential tool to target impaired cardiac autonomic phenotypes.

Cite This Study

Wang et al. (2009) studied this question.

synapsesocial.com/papers/6a83d48362f5b6e6a7fe2c80 https://doi.org/10.1113/jphysiol.2009.172866

View Full Paper

Ask AI

Bookmark

Long‐term effect of neuronal nitric oxide synthase over‐expression on cardiac neurotransmission mediated by a lentiviral vector

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Long‐term effect of neuronal nitric oxide synthase over‐expression on cardiac neurotransmission mediated by a lentiviral vector

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider