Why the study?
Does NOS-1 gene transfer to the right atrium enhance cardiac vagal neurotransmission and bradycardia in a guinea pig model?
Population
Guinea pig model (in vitro and in vivo)
Comparison
Neuronal nitric oxide synthase gene transfer to… vs Control groups
Design
Preclinical
Authors
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Supports presynaptic vagal facilitation in guinea pig models; leaves open translation to human autonomic therapies.
Does NOS-1 gene transfer to the right atrium enhance cardiac vagal neurotransmission and bradycardia in a guinea pig model?
NOS-1 gene transfer facilitates vagally induced bradycardia by acting presynaptically, offering a potential novel approach to increase cardiac vagal function.
Mohan et al. (2002) studied this question.
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