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December 1, 2001AJP Heart and Circulatory Physiology

Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice

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Population

Isolated atrial preparations with an intact right vagus nerve from wild-type and neuronal NO synthase…

Comparison

Vagal nerve stimulation, carbamylcholine… vs nNOS+/+ (wild-type) vs nNOS-/- (knockout) mice

Design

Preclinical

Authors

JCJulia ChoateEDE. DansonJMJ Morris

Discussion

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Overview

nNOS may facilitate vagal bradycardia; animal data leave open relevance to human autonomic regulation.

Structured PICO

P
Population
Isolated atrial preparations with an intact right vagus nerve from wild-type (nNOS+/+, n = 81) and neuronal NO synthase (nNOS) knockout (nNOS-/-, n = 43) mice
I
Intervention
Vagal nerve stimulation (VNS, 3 and 5 Hz), carbamylcholine, selective nNOS inhibitors, guanylyl cyclase inhibitor, and NO donor sodium nitroprusside
C
Comparator
nNOS+/+ (wild-type) vs nNOS-/- (knockout) mice
O
Outcome
Rate of decline in heart rate during vagal nerve stimulationsurrogate

Neuronal nitric oxide facilitates vagally induced bradycardia via presynaptic modulation of neurotransmission.

Cite This Study

Choate et al. (2001) studied this question.

synapsesocial.com/papers/6a7558fbb35e02fb15034719https://doi.org/10.1152/ajpheart.2001.281.6.h2310
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits1996 · 110 citations
  2. 2Properties of the hyperpolarizing‐activated current (if) in cells isolated from the rabbit sino‐atrial node.1986 · 473 citations
  3. 3Changes in extracellular pH mediate the chronotropic responses to ?-arginine1999 · 9 citations
  4. 4Role of the NO‐cGMP pathway in the muscarinic regulation of the L‐type Ca2+ current in human atrial myocytes1998 · 52 citations
  5. 5Positive inotropic effects of NO donors in isolated guinea-pig and human cardiomyocytes independent of NO species and cyclic nucleotides2000 · 28 citations