Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 2000Neuroreport

Role of nitric oxide in the control of the heart rate within the nucleus ambiguus of rats

View Full Paper
Ask AI
Bookmark
Share

Population

29 male Wistar rats anaesthetized with urethane

Design

Preclinical

Authors

PRPiero RuggeriOspedale Policlinico San MartinoABAntonio BattagliaUniversity of MessinaRER ErmirioUniversity of Genoa

Discussion

Loading...

Member takes

Overview

Does not inform clinical practice; leaves open whether nitric oxide mechanisms in the nucleus ambiguus modulate HR across species.

Structured PICO

P
Population
29 male Wistar rats anaesthetized with urethane
I
Intervention
Microinjections of NO-donor sodium nitroprusside (SNP; 5 mmol), L-arginine (L-arg; 50 mmol), or NO-synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME) into functionally identified cardioinhibitory sites within the nucleus ambiguus
O
Outcome
Heart rate (HR)surrogate

Nitric oxide mechanisms within the nucleus ambiguus play a role in the parasympathetic control of heart rate in rats.

Cite This Study

Ruggeri et al. (2000) studied this question.

synapsesocial.com/papers/6a8beecae066a6a97ec45f1ehttps://doi.org/10.1097/00001756-200002280-00011
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits1996 · 110 citations
  2. 2The role of nitric oxide in the control by the vagal nerves of the heart of the ferret1998 · 31 citations
  3. 3Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits.1993 · 275 citations
  4. 4Modulation of vagal actions on heart rate produced by inhibition of nitric oxide synthase in the anaesthetized ferret1996 · 49 citations
  5. 5Pressor and sympathoexcitatory effects of nitric oxide in the rostral ventrolateral medulla1996 · 100 citations