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February 1, 1999Journal of Applied Physiology

NO-cGMP pathway accentuates the decrease in heart rate caused by cardiac vagal nerve stimulation

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Why the study?

Does the addition of NO or cGMP modulate the heart rate response to vagal nerve stimulation in animal models?

Population

Anesthetized rabbits (in vivo) and isolated guinea pig atria (in vitro)

Comparison

Addition of NO donors or cGMP analog during… vs Vagal nerve stimulation without NO donors or…

Design

Preclinical

Authors

CSClaire SearsIndiana University HealthJCJulia ChoateMonash UniversityDPDavid J. PatersonUnited States Nuclear Regulatory Commission

Discussion

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Overview

Should not alter clinical HR management; leaves open cGMP pathways in vagal control for translational research.

Structured PICO

Does the addition of NO or cGMP modulate the heart rate response to vagal nerve stimulation in animal models?

P
Population
Anesthetized rabbits (in vivo) and isolated guinea pig atria (in vitro)
I
Intervention
Addition of NO donors (molsidomine 0.2 mg/kg iv in vivo; sodium nitroprusside 10 and 100 microM in vitro) or cGMP analog (8-bromoguanosine 3',5'-cyclic monophosphate 0.5 mM) during vagal nerve stimulation
C
Comparator
Vagal nerve stimulation without NO donors or cGMP analogs
O
Outcome
Magnitude of decrease in heart rate caused by vagal nerve stimulationsurrogate

Excessive NO enhances the vagally-induced decrease in heart rate via a presynaptic cGMP-dependent pathway.

Cite This Study

Sears et al. (1999) studied this question.

synapsesocial.com/papers/6a83d4465872f04c313e968dhttps://doi.org/10.1152/jappl.1999.86.2.510
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of nitric oxide synthase slows heart rate recovery from cholinergic activation1998 · 49 citations
  2. 2Role of the NO‐cGMP pathway in the muscarinic regulation of the L‐type Ca<sup>2+</sup> current in human atrial myocytes1998 · 51 citations
  3. 3Modulation of vagal actions on heart rate produced by inhibition of nitric oxide synthase in the anaesthetized ferret1996 · 49 citations
  4. 4Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits1996 · 110 citations
  5. 5Nitric Oxide Synthase (NOS3)–Mediated Cholinergic Modulation of Ca<sup>2+</sup>Current in Adult Rabbit Atrioventricular Nodal Cells1996 · 133 citations