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October 3, 2006Hypertension

NO Differentially Regulates Neurotransmission to Premotor Cardiac Vagal Neurons in the Nucleus Ambiguus

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Population

In vitro brain slice preparation in rats (cardiac vagal preganglionic neurons in the nucleus ambiguus)

Design

Preclinical

Authors

HKHarriet KamendiAstraZeneca (United Kingdom)ODOlga DergachevaGeorge Washington UniversityXWXin WangThe Fourth People's Hospital of Zibo City

Discussion

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Overview

Does not inform clinical vagal tone management; leaves open translation of nitric oxide's differential synaptic effects to human autonomic control.

Structured PICO

P
Population
In vitro brain slice preparation in rats (cardiac vagal preganglionic neurons in the nucleus ambiguus)
I
Intervention
NO donor sodium nitroprusside (SNP, 100 micromol/L) and precursor l-arginine (10 mmol/L)
O
Outcome
Frequency and amplitude of glutamatergic, GABAergic, and glycinergic synaptic eventssurrogate

Nitric oxide differentially regulates neurotransmission to cardiac vagal neurons, facilitating GABAergic and diminishing glutamatergic and glycinergic activity.

Cite This Study

Kamendi et al. (2006) studied this question.

synapsesocial.com/papers/6a8beecae066a6a97ec45f1bhttps://doi.org/10.1161/01.hyp.0000246493.00385.94
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA1998 · 235 citations
  2. 2Nicotine Enhances Presynaptic and Postsynaptic Glutamatergic Neurotransmission to Activate Cardiac Parasympathetic Neurons1998 · 62 citations
  3. 3Role of nitric oxide in the control of the heart rate within the nucleus ambiguus of rats2000 · 25 citations
  4. 4Nitric oxide donors can increase heart rate independent of autonomic activation1999 · 45 citations
  5. 5Advances in Parasympathetic Control of Heart Rate and Cardiac Function1999 · 160 citations