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January 1, 2003The Journal of PhysiologyOpen Access

Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise‐trained mice

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Why the study?

Does 10 weeks of voluntary wheel-running improve cardiac vagal responsiveness via NOS-1 in male mice?

Population

54 male mice (18-22 weeks old), from which isolated atria with intact right vagal innervation were taken.

Comparison

10 weeks of voluntary wheel-running vs Housed in cages without wheels for 10 weeks

Design

Preclinical

Follow-up

10 weeks

Authors

EDE. DansonDPDavid J. Paterson

Discussion

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Overview

Hypothesis-generating for NOS-1 mediation of exercise-enhanced vagal tone in mice; human studies required before any clinical consideration.

Structured PICO

Does 10 weeks of voluntary wheel-running improve cardiac vagal responsiveness via NOS-1 in male mice?

P
Population
54 male mice (18-22 weeks old), from which isolated atria with intact right vagal innervation were taken.
I
Intervention
10 weeks of voluntary wheel-running (peaked 9.8 +/- 0.6 km/day at 5 weeks)
C
Comparator
Housed in cages without wheels for 10 weeks
O
Outcome
Heart rate responses to vagal stimulation and NOS-1 protein levels in isolated atriasurrogate

Exercise training enhances cardiac vagal responsiveness in mice through a mechanism dependent on neuronal nitric oxide synthase (NOS-1).

Cite This Study

Danson et al. (2003) studied this question.

synapsesocial.com/papers/6a7558fbb35e02fb15034714https://doi.org/10.1113/jphysiol.2002.031781
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.1994 · 941 citations
  2. 2Nitric Oxide Facilitates Vagal Control of Heart Rate Via Actions in the Cardiac Parasympathetic Ganglia of the Anaesthetised Dog2002 · 19 citations
  3. 3Exercise Training Augments Flow-Dependent Dilation in Rat Skeletal Muscle Arterioles1995 · 245 citations
  4. 4Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors.1993 · 225 citations
  5. 5Different types of ganglion cell in the cardiac plexus of guinea‐pigs.1995 · 109 citations