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May 25, 2004The Journal of PhysiologyOpen Access

Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele

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Population

Heterozygous nNOS knockout mice (nNOS+/-, n=52) and wild-type mice (n=38)

Comparison

Voluntary wheel-running exercise and targeted in… vs Wild-type mice, sedentary controls, and gene…

Design

Preclinical

Authors

EDE. DansonUniversity of WollongongKMKulveer MankiaUniversity of LeedsSGS GoldingRoche (Switzerland)

Discussion

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Overview

Should not change clinical practice; hypothesis-generating for nNOS gene therapy in autonomic dysfunction.

Structured PICO

P
Population
Heterozygous nNOS knockout mice (nNOS+/-, n=52) and wild-type mice (n=38)
I
Intervention
Voluntary wheel-running exercise and targeted in vivo nNOS gene transfer using adenoviruses to atrial ganglia
C
Comparator
Wild-type mice, sedentary controls (-EX), and gene transfer of enhanced green fluorescent protein (eGFP)
O
Outcome
Heart rate response to phenylephrine-induced bradycardia and vagal nerve stimulationsurrogate

Genomic regulation of NO bioavailability from nNOS in cardiac autonomic ganglia during exercise training requires both alleles, and targeted gene transfer can restore impaired neural regulation of heart rate.

Cite This Study

Danson et al. (2004) studied this question.

synapsesocial.com/papers/6a6ff3b4febe604dd708c4b0https://doi.org/10.1113/jphysiol.2004.062299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise‐trained mice2003 · 73 citations
  2. 2Conditional Neuronal Nitric Oxide Synthase Overexpression Impairs Myocardial Contractility2007 · 101 citations
  3. 3Sympathetic control of heart rate in nNOS knockout mice2007 · 17 citations
  4. 4Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice.1998 · 121 citations
  5. 5Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice2001 · 93 citations