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October 19, 2007AJP Heart and Circulatory Physiology

Sympathetic control of heart rate in nNOS knockout mice

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Why the study?

Does genetic deletion of nNOS alter sympathetic heart rate responses in isolated mouse atria?

Population

Isolated atria from mice with selective genetic disruption of nNOS (nNOS) and their wild-type littermates

Comparison

Genetic deletion of nNOS (nNOS(-/-) mice) vs Wild-type (WT) littermates

Design

Preclinical

Authors

JCJulia ChoateMonash UniversitySMS M MurphyThe University of MelbourneRFRoss D. FeldmanGeneral / Preventive / Lipids

Discussion

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Overview

nNOS deletion blunts sympathetic HR responses in mouse atria; hypothesis-generating for human sinoatrial node regulation and requires translational validation.

Structured PICO

Does genetic deletion of nNOS alter sympathetic heart rate responses in isolated mouse atria?

P
Population
Isolated atria from mice with selective genetic disruption of nNOS (nNOS(-/-)) and their wild-type littermates (WT)
I
Intervention
Genetic deletion of nNOS (nNOS(-/-) mice)
C
Comparator
Wild-type (WT) littermates
O
Outcome
Heart rate (HR) responses to sympathetic nerve activation and norepinephrinesurrogate

Genetic deletion of nNOS in mice results in reduced heart rate responses to sympathetic activation, likely due to inhibition of adrenergic-adenylate cyclase signaling within sinoatrial node myocytes rather than presynaptic modulation.

Cite This Study

Choate et al. (2007) studied this question.

synapsesocial.com/papers/6a7558fbb35e02fb15034710https://doi.org/10.1152/ajpheart.00898.2007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endogenous and Exogenous Nitric Oxide Inhibits Norepinephrine Release From Rat Heart Sympathetic Nerves1995 · 276 citations
  2. 2Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice2001 · 93 citations
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  4. 4Noradrenergic Cell Specific Gene Transfer With Neuronal Nitric Oxide Synthase Reduces Cardiac Sympathetic Neurotransmission in Hypertensive Rats2007 · 60 citations
  5. 5Gene Transfer of Neuronal Nitric Oxide Synthase into Intracardiac Ganglia Reverses Vagal Impairment in Hypertensive Rats2007 · 41 citations