Why the study?
Does exercise training reduce the heart rate response to sympathetic activation via a peripheral NO-dependent pathway in guinea pigs?
Population
Guinea pigs, n=40. Isolated double atrial/right stellate ganglion preparation.
Comparison
6-weeks swimming exercise training vs Sedentary lifestyle
Design
Preclinical
Follow-up
6 weeks
Authors
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Attenuates sympathetic HR response via peripheral pre-synaptic, NO-independent mechanism in guinea pigs; leaves open human translation and clinical relevance.
Does exercise training reduce the heart rate response to sympathetic activation via a peripheral NO-dependent pathway in guinea pigs?
Exercise training attenuates the heart rate response to sympathetic activation through a peripheral pre-synaptic mechanism, though nitric oxide does not play a dominant role.
Ravi Mohan (2000) studied this question.
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