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July 1, 2001AJP Heart and Circulatory Physiology

Intermittent hypoxia modulates nNOS expression and heart rate response to sympathetic nerve stimulation

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Why the study?

Does chronic intermittent hypoxia enhance heart rate response to sympathetic nerve stimulation in guinea pig atrial preparations?

Population

Isolated guinea pig double atrial/right stellate ganglion preparations from animals exposed to chronic…

Comparison

Chronic intermittent hypoxia (IH) vs Control (no intermittent hypoxia exposure)

Design

Preclinical

Authors

RMRavi MohanSri Balaji Vidyapeeth UniversitySGS GoldingRoche (Switzerland)DPDavid J. PatersonUnited States Nuclear Regulatory Commission

Discussion

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Overview

May link intermittent hypoxia to atrial sympathetic hyperactivity; leaves open translation to human sleep apnea or arrhythmia risk.

Structured PICO

Does chronic intermittent hypoxia enhance heart rate response to sympathetic nerve stimulation in guinea pig atrial preparations?

P
Population
Isolated guinea pig double atrial/right stellate ganglion preparations from animals exposed to chronic intermittent hypoxia (n=20) and control animals (n=22)
I
Intervention
Chronic intermittent hypoxia (IH)
C
Comparator
Control (no intermittent hypoxia exposure)
O
Outcome
Heart rate (HR) response to sympathetic nerve stimulation (SNS)surrogate

Chronic intermittent hypoxia enhances heart rate response to sympathetic nerve stimulation, likely due to decreased inhibitory action of nitric oxide on presynaptic norepinephrine release.

Cite This Study

Mohan et al. (2001) studied this question.

synapsesocial.com/papers/6a8930dfeb3171c94f2000a9https://doi.org/10.1152/ajpheart.2001.281.1.h132
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuronal Nitric Oxide Reduces Sympathetic Excitability by Modulation of Central Glutamate Effects in Pigs1997 · 59 citations
  2. 2Catecholamines, hypoxia and high altitude1998 · 127 citations
  3. 3Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure1991 · 189 citations
  4. 4Effects of hypoxia on density of beta-adrenergic receptors1981 · 123 citations