What does this research mean for the field?

Neuronally derived nitric oxide and cardiac inhibitory G protein activity serve as parallel pathways to mediate autonomic slowing of heart rate. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1998Journal of Clinical InvestigationOpen Access

Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice.

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Population

48 conscious mice (24 wild-type and 24 nNOS-/- mice)

Comparison

Neuronal NO synthase gene deletion and… vs Wild-type (WT) mice

Design

Preclinical

Authors

PJPitayadet JumrussirikulIowa Department of Education JDJay DinermanElectrophysiology TDTM DawsonJohns Hopkins University

Discussion

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Implication

nNOS-/- mice show altered HR control; extends preclinical support for neuronal NO in autonomic slowing but leaves open human relevance.

Structured PICO

Population

48 conscious mice (24 wild-type and 24 nNOS-/- mice)

Intervention

Neuronal NO synthase (nNOS) gene deletion (nNOS-/-) and pharmacological autonomic blockade/pressor challenge (atropine, propranolol, phenylephrine, pertussis toxin)

Comparator

Wild-type (WT) mice

Outcome

Mean heart rate and heart rate variability (variance)surrogate

The study demonstrates that neuronally derived nitric oxide and cardiac inhibitory G proteins act as parallel pathways in mediating autonomic slowing of heart rate in mice.

Cite This Study

Jumrussirikul et al. (1998) studied this question.

synapsesocial.com/papers/6a1957f2f2eb401dc788f443 https://doi.org/10.1172/jci2843

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Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider