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January 9, 2007Hypertension

Gene Transfer of Neuronal Nitric Oxide Synthase into Intracardiac Ganglia Reverses Vagal Impairment in Hypertensive Rats

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Why the study?

Does gene transfer of adenoviral nNOS improve cardiac vagal responsiveness in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats

Comparison

Gene transfer of adenoviral neuronal NO synthase… vs Transfection with adenoviral enhanced green…

Design

Preclinical

Authors

DHDaniel A. HeatonDLDan LiSASusanna C Almond

Discussion

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Overview

Supports nNOS gene therapy investigation in hypertension models; leaves open translation to human autonomic therapies.

Structured PICO

Does gene transfer of adenoviral nNOS improve cardiac vagal responsiveness in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats
I
Intervention
Gene transfer of adenoviral neuronal NO synthase (nNOS) into the right atrium
C
Comparator
Transfection with adenoviral enhanced green fluorescent protein
O
Outcome
Cardiac vagal heart rate responses (vagal responsiveness in vivo)surrogate

Gene transfer of nNOS into intracardiac ganglia reverses cardiac vagal dysfunction in hypertensive rats by restoring the postganglionic presynaptic NO-cGMP pathway.

Cite This Study

Heaton et al. (2007) studied this question.

synapsesocial.com/papers/6a7558fbb35e02fb15034712https://doi.org/10.1161/01.hyp.0000255792.97033.f7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise‐trained mice2003 · 73 citations
  2. 2NO Differentially Regulates Neurotransmission to Premotor Cardiac Vagal Neurons in the Nucleus Ambiguus2006 · 14 citations
  3. 3Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one <i>nNOS</i> allele2004 · 28 citations
  4. 4NO-cGMP pathway accentuates the decrease in heart rate caused by cardiac vagal nerve stimulation1999 · 61 citations
  5. 5Role of endogenous nitric oxide in the nucleus tratus solitarii on baroreflex control of heart rate in spontaneously hypertensive rats1998 · 54 citations