Why the study?
Does right-sided congestive heart failure alter vagal control over heart rate and nNOS/M2 receptor expression in rats?
Population
Rats with right-sided congestive heart failure (CHF) induced by monocrotaline
Comparison
Pre- and post-ganglionic vagal nerve stimulation… vs Control rats
Design
Preclinical
Authors
Loading...
May indicate multi-level vagal impairment in right-sided CHF; hypothesis-generating and leaves open human translation.
Does right-sided congestive heart failure alter vagal control over heart rate and nNOS/M2 receptor expression in rats?
In a rat model of right-sided CHF, parasympathetic withdrawal is characterized by diminished pre- and post-ganglionic vagal nerve functions and downregulation of nNOS, despite upregulation of M2 receptor-mediated regulation.
Nihei et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: