Ganglionic Mechanisms Contribute to Diminished Vagal Control in Heart Failure
Key result
Postganglionic stimulation under ganglionic and beta-adrenergic blockade in a canine heart failure model yielded higher sinus cycle length changes versus controls (76 vs 20 ms; P<0.01).
Why the study?
Does heart failure alter the sinus cycle length response to preganglionic and postganglionic parasympathetic stimulation in a canine model?
Population
Paced canine model of heart failure (n=8) and control dogs (n=8)
Comparison
Electrical stimulation of preganglionic and… vs Control dogs without heart failure
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports ganglionic localization of parasympathetic dysfunction in canine HF; leaves open clinical translation.
Structured PICO
Does heart failure alter the sinus cycle length response to preganglionic and postganglionic parasympathetic stimulation in a canine model?
P
Population
Paced canine model of heart failure (n=8) and control dogs (n=8)
I
Intervention
Electrical stimulation of preganglionic (cervical vagus) and postganglionic (right atrial fat pad) parasympathetic neurons innervating the sinoatrial node
C
Comparator
Control dogs without heart failure
O
Outcome
Sinus cycle length changes in response to electrical stimulationsurrogate
Main Result
Absolute Event Rate: 76% vs 20%
p-value: p=<0.01
In a canine model of heart failure, attenuated parasympathetic control is partly localized to a defect within the parasympathetic ganglion of the peripheral efferent limb.
Cite This Study
Bibevski et al. (1999) studied Heart Failure (canine model) (n=16). Electrical stimulation of preganglionic and postganglionic parasympathetic neurons vs. Control dogs was evaluated on Sinus cycle length changes in response to electrical stimulation under ganglionic and beta-adrenergic blockade (p=<0.01). Postganglionic stimulation under ganglionic and beta-adrenergic blockade in a canine heart failure model yielded higher sinus cycle length changes versus controls (76 vs 20 ms; P<0.01).