Why the study?
What are the mechanisms and sites of altered vagal control in a canine model of heart failure?
What are the mechanisms and sites of altered vagal control in a canine model of heart failure?
In a canine model of heart failure, reduced vagal control is likely due to presynaptic changes, as postsynaptic mechanisms (upregulated muscarinic receptors and reduced acetylcholinesterase) actually augment vagal control.
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Postsynaptic muscarinic upregulation may augment vagal tone in HF models; leaves open presynaptic mechanisms for targeted research.
Dunlap et al. (2003) studied this question.
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