Population
18 dogs (8 sham-operated and 10 with pacing-induced heart failure at 240 bpm for 4 to 7 weeks)
Comparison
Pacing-induced heart failure and subsequent… vs Sham-operated dogs
Design
Preclinical
Follow-up
4 to 7 weeks
Authors
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May indicate heightened muscarinic inhibition of contractility in HF; leaves open translation to human disease or therapy.
Pacing-induced heart failure in dogs leads to coordinate increases in muscarinic receptor number and Gi levels, which are coupled to increased inhibition of adenylyl cyclase activity and myocardial contractility.
Vatner et al. (1996) studied this question.
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