Population
Pigs with pacing-induced congestive heart failure
Design
Preclinical
Authors
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G-protein downregulation in porcine CHF extends prior animal data; leaves open relevance to human HF signaling and therapy.
In a porcine model of pacing-induced heart failure, both stimulatory and inhibitory G-proteins are downregulated uniformly in the right atrium and left ventricle, likely due to increased degradation.
Roth et al. (1993) studied this question.
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