Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
Why the study?
Does experimentally induced hypertension alter adenylate cyclase activity and Gi alpha protein levels in cardiac hypertrophy before the onset of heart failure?
Population
Rats with different forms of experimentally induced hypertension without heart failure
Comparison
Experimentally induced hypertension vs Sham-operated, age-matched control rats
Design
Preclinical
Authors
Discussion
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Implication
May underlie early myocardial depression in hypertension; hypothesis-generating for Gi pathways in human hypertrophy before heart failure.
Structured PICO
Does experimentally induced hypertension alter adenylate cyclase activity and Gi alpha protein levels in cardiac hypertrophy before the onset of heart failure?
P
Population
Rats with different forms of experimentally induced hypertension without heart failure (one-kidney, one clip rats, deoxycorticosterone-treated rats, and rats with reduced renal mass)
I
Intervention
Experimentally induced hypertension (one-kidney, one clip; deoxycorticosterone; reduced renal mass)
C
Comparator
Sham-operated, age-matched control rats
O
Outcome
Adenylate cyclase activity and Gi alpha protein levels in myocardial membranessurrogate
Enhanced expression of Gi alpha and reduced adenylate cyclase activity occur in cardiac hypertrophy before the onset of heart failure, potentially contributing to myocardial depression and disease progression.
Cite This Study
Böhm et al. (1992) studied this question.