Population
One kidney one clip (1K-1C) hypertensive rats
Comparison
Captopril vs Control rats and untreated 1K-1C hypertensive rats
Design
Preclinical
Authors
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Attributes Gialpha changes to Ang II in rat hypertension; leaves open human relevance and therapeutic targeting.
In a 1K-1C hypertensive rat model, enhanced expression of Gialpha proteins and altered adenylyl cyclase activity are attributable to elevated Angiotensin II, as these changes are reversed by captopril.
Ge et al. (1999) studied this question.
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