April 1, 1993Journal of Hypertension

G-proteins in experimental hypertension: a study of spontaneously hypertensive rat myocardial and renal cortical plasma membranes

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Population

11-week-old spontaneously hypertensive rats weighing 255 g, and control rats from Wistar-Kyoto and Wistar…

Comparison

Assessment of G-protein expression and… vs Wistar-Kyoto (WKY) and Wistar control rats

Design

Preclinical

Authors

AMAlastair R. McLellanWestern Infirmary GMGraeme MilliganHeart Failure & Transplant MHMiles D. HouslayHeart Failure & Transplant

Discussion

Member takes

Implication

Strain confounds may explain adenylyl cyclase differences in SHR models; leaves open hypertension-specific effects on myocardial Gs signaling.

Structured PICO

Population

11-week-old spontaneously hypertensive rats (SHR) weighing 255 g, and control rats from Wistar-Kyoto (WKY) and Wistar strains

Intervention

Assessment of G-protein expression and functioning in myocardial and renal cortical plasma membranes

Comparator

Wistar-Kyoto (WKY) and Wistar control rats

Outcome

Adenylyl cyclase activity and levels of G-protein subunits (Gs alpha, Gi alpha 1, Gi alpha 2, Gi alpha 3, Go alpha and beta)surrogate

Differences in myocardial adenylyl cyclase activity in spontaneously hypertensive rats compared to controls are likely due to strain differences in Gs function rather than hypertension or G-protein levels.

Cite This Study

McLellan et al. (1993) studied this question.

synapsesocial.com/papers/6a87c4b2b9eac34b90062079 https://doi.org/10.1097/00004872-199304000-00006

Topics

Hypertension management

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Implication

Strain confounds may explain adenylyl cyclase differences in SHR models; leaves open hypertension-specific effects on myocardial Gs signaling.