Population
Freshly isolated preglomerular resistance arterioles obtained from kidneys of 7-week-old spontaneously…
Comparison
Stimulation with prostaglandin E2, prostaglandin… vs Arterioles from normotensive Wistar-Kyoto rats
Design
Preclinical
Authors
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Impaired cAMP signaling in hypertensive rat arterioles; leaves open whether receptor-G protein uncoupling contributes to human hypertension.
The study identifies defective coupling of prostaglandin and beta-adrenergic receptors to stimulatory G proteins as a cellular mechanism for impaired vasodilation in young spontaneously hypertensive rats.
Ruan et al. (1999) studied this question.
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