Key result
In a canine model of pressure overload, Gs activity and Gs alpha mRNA levels decreased by approximately 30% during compensated left ventricular hypertrophy before the onset of heart failure.
Population
Animals with normal hearts, pressure overload-induced left ventricular hypertrophy, and heart failure
Comparison
Pressure overload-induced left ventricular… vs Normal (NL) animals
Design
Preclinical
Authors
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May signal early Gs impairment in compensated hypertrophy; leaves open its role in human HF transition.
Absolute Event Rate: 3% vs 4.2%
p-value: p=<0.05
Gs and adenylyl cyclase activities fall in parallel with the development of LV hypertrophy, followed by a further Gs-independent decrement in adenylyl cyclase in the setting of heart failure.
Chen et al. (1991) studied Left ventricular hypertrophy and heart failure (n=29). Aortic banding (pressure overload) vs. Normal/sham-operated controls was evaluated on Gs functional activity (pmol cyclic AMP/10 min per μg) (p=<0.05). In a canine model of pressure overload, Gs activity and Gs alpha mRNA levels decreased by approximately 30% during compensated left ventricular hypertrophy before the onset of heart failure.
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