Key result
Vagomimetic doses of atropine increased R-R interval (419 to 466 ms, P<0.05) and its standard deviation (13 to 34 ms, P<0.05) in dogs with heart failure.
Why the study?
Do alterations in vagal and sympathetic control of heart rate occur early in the development of left ventricular dysfunction and heart failure in a canine model?
Do alterations in vagal and sympathetic control of heart rate occur early in the development of left ventricular dysfunction and heart failure in a canine model?
p-value: p=<0.05
Changes in vagal control of heart rate become apparent at a very early developmental stage of LV dysfunction, preceding overt heart failure.
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Preserved vagal responsiveness in canine HF; hypothesis-generating for autonomic modulation before human translation.
Kinugawa et al. (1995) studied Left ventricular dysfunction and heart failure. Atropine and deslanoside vs. Baseline was evaluated on R-R interval and standard deviation of the R-R interval (p=<0.05). Vagomimetic doses of atropine increased R-R interval (419 to 466 ms, P<0.05) and its standard deviation (13 to 34 ms, P<0.05) in dogs with heart failure.
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