Why the study?
Does intracoronary acetylcholine or atropine alter cardiac norepinephrine spillover in patients with congestive heart failure compared to those with normal LV function?
Does intracoronary acetylcholine or atropine alter cardiac norepinephrine spillover in patients with congestive heart failure compared to those with normal LV function?
The study demonstrates that patients with heart failure lack basal parasympathetic inhibition of cardiac sympathetic activity, though muscarinic receptor stimulation can still decrease cardiac norepinephrine spillover.
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Supports absent basal parasympathetic inhibition of cardiac sympathetic activity in CHF; hypothesis-generating for autonomic-targeted therapies.
Azevêdo et al. (1999) studied this question.
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