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January 1, 2002Experimental Physiology

Inhibition of neuronally released NO with TRIM reduced bradycardia evoked by preganglionic but not postganglionic vagal stimulation, indicating NO facilitates vagal control at parasympathetic ganglia.

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Population

Anaesthetised dog preparation following transection of the cervical vagi and in the presence of a…

Design

Preclinical

Key result

Inhibition of neuronally released NO with TRIM reduced bradycardia evoked by preganglionic but not postganglionic vagal stimulation, indicating NO facilitates vagal control at parasympathetic ganglia.

Authors

FMF. MarkosHSH. M. SnowCKC. Kidd

Discussion

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Overview

NO facilitation at cardiac ganglia may guide autonomic research; leaves open translation to human vagal therapies.

Structured PICO

P
Population
Anaesthetised dog preparation following transection of the cervical vagi and in the presence of a beta-adrenoreceptor antagonist.
I
Intervention
Injection of 1-(2-trifluoromethylphenyl) imidazole (TRIM), an inhibitor of neuronally released NO, into the sinus node artery
O
Outcome
Bradycardia resulting from stimulation of preganglionic and postganglionic parasympathetic fibressurrogate

This study demonstrates that neuronally released nitric oxide facilitates vagal control of heart rate primarily at the preganglionic-postganglionic synaptic level in cardiac parasympathetic ganglia.

Cite This Study

Markos et al. (2002) studied this question. 1-(2-trifluoromethylphenyl) imidazole (TRIM) was evaluated on Bradycardia resulting from stimulation of preganglionic and postganglionic parasympathetic fibres. Inhibition of neuronally released NO with TRIM reduced bradycardia evoked by preganglionic but not postganglionic vagal stimulation, indicating NO facilitates vagal control at parasympathetic ganglia.

synapsesocial.com/papers/6a9d4fc5ef6cfb4b18fce2dfhttps://doi.org/10.1113/eph8702303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of nitric oxide in the control by the vagal nerves of the heart of the ferret1998 · 31 citations
  2. 2Modulation of vagal actions on heart rate produced by inhibition of nitric oxide synthase in the anaesthetized ferret1996 · 49 citations
  3. 3Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs.1995 · 175 citations
  4. 4Inhibition of Neuronal Nitric Oxide Reduces Heart Rate Variability in the Anaesthetised Dog2001 · 16 citations
  5. 5Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice2001 · 93 citations