Why the study?
Does inhibition of neuronal nitric oxide with TRIM reduce heart rate variability in anaesthetised dogs?
Does inhibition of neuronal nitric oxide with TRIM reduce heart rate variability in anaesthetised dogs?
Inhibition of neuronal nitric oxide reduces heart rate variability in anaesthetised dogs, suggesting NO has a vagal facilitatory role in maintaining sinus arrhythmia.
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Suggests neuronal NO facilitates vagal sinus arrhythmia control in dogs; hypothesis-generating for human autonomic regulation.
In the vagally intact anaesthetised dog, we have investigated the role of nitric oxide (NO) on a normal sinus arrhythmia using an inhibitor of neuronally released NO, 1-(2-trifluoromethylphenyl) imidazole (TRIM). The mean and S.D. of the R-R interval was used to describe mean heart rate and heart rate variability, respectively. TRIM (0.8 mg I.C.) injected into the sinus node artery increased the mean heart rate slightly but reduced heart rate variability 3-fold from a control of 790 +/- 124 ms (mean +/- S.D.; n = 5) to 666 +/- 36 ms (P < 0.01 Student's paired t test, n = 5). These results suggest that neuronally released NO may have a vagal facilitatory role in the maintenance of sinus arrhythmia in the normal heart.
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Markos et al. (2001) studied this question.
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