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September 1, 2001Experimental PhysiologyOpen Access

TRIM reduced heart rate variability 3-fold from a control of 790 +/- 124 ms to 666 +/- 36 ms (P < 0.01).

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Why the study?

Does inhibition of neuronal nitric oxide with TRIM reduce heart rate variability in anaesthetised dogs?

Population

Vagally intact anaesthetised dogs (n=5)

Comparison

1- imidazole 0.8 mg injected intracoronary into… vs Control (baseline before injection)

Design

Preclinical

Authors

FMF. MarkosHSH. M. SnowCKC. Kidd

Discussion

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Overview

Suggests neuronal NO facilitates vagal sinus arrhythmia control in dogs; hypothesis-generating for human autonomic regulation.

Structured PICO

Does inhibition of neuronal nitric oxide with TRIM reduce heart rate variability in anaesthetised dogs?

P
Population
Vagally intact anaesthetised dogs (n=5)
I
Intervention
1-(2-trifluoromethylphenyl) imidazole (TRIM) 0.8 mg injected intracoronary (I.C.) into the sinus node artery
C
Comparator
Control (baseline before injection)
O
Outcome
Heart rate variability (S.D. of the R-R interval) and mean heart rate (mean of the R-R interval)surrogate

Inhibition of neuronal nitric oxide reduces heart rate variability in anaesthetised dogs, suggesting NO has a vagal facilitatory role in maintaining sinus arrhythmia.

Cite This Study

Markos et al. (2001) studied this question.

synapsesocial.com/papers/6a83d3e762f5b6e6a7fe2c0bhttps://doi.org/10.1113/eph8602257
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