Why the study?
Does lovastatin improve cerebral arteriolar mechanics and CBF autoregulation in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) (n=21) and Wistar-Kyoto rats (WKY) (n=8)
Comparison
Lovastatin 20 mg/kg/day for 1 month vs Untreated SHR (n=9) and untreated WKY rats (n=8)
Design
Preclinical
Follow-up
1 month
Authors
Loading...
Hypothesis-generating for statin effects on hypertensive arteriolar remodeling; leaves open translation to human CBF autoregulation.
Does lovastatin improve cerebral arteriolar mechanics and CBF autoregulation in spontaneously hypertensive rats?
Lovastatin normalizes cerebral arteriolar wall cross-sectional area and mechanics in hypertensive rats but does not alter internal diameter or cerebral blood flow autoregulation.
Régrigny et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: