Key result
Pravastatin treatment for 4 weeks in spontaneously hypertensive rats significantly reduced systolic blood pressure compared to controls (159 vs 171 mmHg, P<0.05).
Why the study?
Does pravastatin reduce blood pressure and prevent early cardiovascular changes in young spontaneously hypertensive rats?
Population
Eight-week-old spontaneously hypertensive rats (SHR)
Comparison
Pravastatin 20 mg kg(-1) day(-1) for 4 weeks vs Control SHR
Design
Preclinical
Follow-up
4 weeks
Authors
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May support early statin effects in genetic hypertension models; leaves open human translation and clinical relevance.
Does pravastatin reduce blood pressure and prevent early cardiovascular changes in young spontaneously hypertensive rats?
Absolute Event Rate: 159% vs 171%
p-value: p=< 0.05
In a rat model of spontaneous hypertension, chronic pravastatin treatment attenuated blood pressure increases, prevented early left ventricular hypertrophy, and improved vascular function and structure.
Kassan et al. (2009) studied Hypertension (spontaneously hypertensive rats). Pravastatin vs. Control SHR was evaluated on Systolic blood pressure (p=< 0.05). Pravastatin treatment for 4 weeks in spontaneously hypertensive rats significantly reduced systolic blood pressure compared to controls (159 vs 171 mmHg, P<0.05).
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