Key result
Two-week pravastatin treatment significantly reduced cardiac angiotensin II levels and normalized cardiac sympathetic hyper-responsiveness in spontaneously hypertensive rats.
Why the study?
Does pravastatin reduce peripheral cardiac sympathetic neurotransmission in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) aged 16-18 weeks, and normotensive Wistar-Kyoto (WKY) rats
Comparison
Pravastatin supplementation for 2 weeks vs Non-supplemented SHRs and normotensive WKYs
Design
Preclinical
Follow-up
2 weeks
Authors
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Hypothesis-generating in hypertensive models; leaves open translation to human sympathetic regulation.
Does pravastatin reduce peripheral cardiac sympathetic neurotransmission in spontaneously hypertensive rats?
p-value: p=<0.05
Pravastatin normalizes cardiac sympathetic hyper-responsiveness in spontaneously hypertensive rats by reducing cardiac angiotensin II levels, independent of cholesterol lowering.
Herring et al. (2010) studied Hypertension. Pravastatin vs. Non-supplemented SHRs and normotensive WKYs was evaluated on Atrial (3)H-norepinephrine release to field stimulation (p=<0.05). Two-week pravastatin treatment significantly reduced cardiac angiotensin II levels and normalized cardiac sympathetic hyper-responsiveness in spontaneously hypertensive rats.
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