Key result
Oral administration of atorvastatin (20 mg/kg/day) for 28 days significantly improved baroreflex sensitivity in stroke-prone spontaneously hypertensive rats.
Why the study?
Does atorvastatin improve impaired baroreflex sensitivity in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats (SHRSPs)
Comparison
Atorvastatin 20 mg/kg/day orally for 28 days vs Vehicle orally for 28 days
Design
Preclinical
Follow-up
28 days
Authors
Loading...
Should not change clinical practice; hypothesis-generating for statin effects on baroreflex sensitivity in hypertensive models.
Does atorvastatin improve impaired baroreflex sensitivity in stroke-prone spontaneously hypertensive rats?
Atorvastatin improves impaired baroreflex sensitivity in a hypertensive rat model via central antioxidant effects, independent of blood pressure reduction.
Kishi et al. (2009) studied Hypertension. Atorvastatin vs. vehicle was evaluated on Baroreflex sensitivity. Oral administration of atorvastatin (20 mg/kg/day) for 28 days significantly improved baroreflex sensitivity in stroke-prone spontaneously hypertensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: