Key result
Atorvastatin improves antioxidant defenses and reduces brain oxidative stress in hypertensive rats.
Why the study?
Brain oxidative stress is a serious complication of arterial hypertension that causes brain tissue damage, and the effects of atorvastatin as an antioxidant in this context were examined.
Does atorvastatin prevent brain tissue oxidative stress in hypertensive rats?
Does atorvastatin prevent brain tissue oxidative stress in hypertensive rats?
Atorvastatin may protect brain tissue from hypertension-induced oxidative stress in a rat model.
Atorvastatin may mitigate hypertension-induced brain oxidative stress in rats; hypothesis-generating for clinical neuroprotection studies.
BACKGROUND: It is well known that the development of brain oxidative stress is one of the most serious complications of arterial hypertension that evokes brain tissue damage. The aim of this study was to examine the effects of atorvastatin treatment (20 mg/kg/day), as an antioxidant, to prevent the brain tissue oxidative stress in the hypertensive (HTN) rats. METHODS: Experiments were performed in four groups of rats (n = 5 each group): sham, sham-treated, HTN and HTN treated. Rats were made HTN by aortic constriction above the renal arteries. After 30 days, rats were slaughtered under deep anesthesia to remove brain hemispheres. After tissue homogenization, enzyme activities of superoxide dismutase (SOD) and catalase (CAT), as well as glutathione (GSH) content and malondialdehyde (MDA) level were determined by biochemical methods. RESULTS: In HTN rats, arterial blood pressure was increased about 40% and brain enzyme activities of SOD and CAT were significantly decreased compared with sham group. Induction of hypertension significantly decreased GSH content and increased MDA level of brain tissue. Treatment with atorvastatin enhanced the activity of SOD and prevented from GSH decrement during hypertension. CONCLUSION: Based on the findings of this study, treatment with atorvastatin might have saved the brain tissue of HTN rats from hypertension-induced oxidative stress.
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Mohammadi et al. (1996) studied Hypertension-induced oxidative stress (n=20). Atorvastatin vs. Untreated hypertensive rats and sham groups was evaluated on Brain enzyme activities of SOD and CAT, GSH content, and MDA level. Treatment with atorvastatin (20 mg/kg/day) enhanced superoxide dismutase activity and prevented glutathione decrement in the brain tissue of hypertensive rats.
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