Why the study?
Does pravastatin reduce the development of left ventricular hypertrophy in spontaneously hypertensive rats?
Population
Normolipidemic spontaneously hypertensive rats at the age of 8 weeks
Comparison
Pravastatin for 8 weeks vs Vehicle, bosentan, mevalonate, hydralazine, or…
Design
Preclinical
Follow-up
8 weeks
Authors
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Supports statin pleiotropy on LVH in hypertensive models; leaves open human translation.
Does pravastatin reduce the development of left ventricular hypertrophy in spontaneously hypertensive rats?
Pravastatin attenuates the development of left ventricular hypertrophy in spontaneously hypertensive rats, likely by decreasing cardiac endothelin-1 levels independent of its hemodynamic and hypolipidemic effects.
Lee et al. (2005) studied this question.
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