Why the study?
Does simvastatin therapy normalize sympathetic neural control and improve left ventricular function in experimental heart failure?
Population
36 male New Zealand White rabbits (13 normal and 23 with pacing-induced chronic heart failure)
Comparison
Simvastatin therapy vs CHF control group
Design
Preclinical
Authors
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Supports hypothesis-generating role for statins in experimental HF autonomic modulation; no implications for patient care yet.
Does simvastatin therapy normalize sympathetic neural control and improve left ventricular function in experimental heart failure?
Simvastatin normalizes autonomic function and improves left ventricular ejection fraction in experimental heart failure by inhibiting central angiotensin II and superoxide pathways.
Gao et al. (2005) studied this question.
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