Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase
Why the study?
Does atorvastatin improve survival and cardiac remodeling after myocardial infarction in an eNOS-dependent manner?
Population
Wild-type (WT) and eNO synthase (eNOS)-/- mice with extensive anterior myocardial infarction (n=117)
Comparison
Atorvastatin 50 mg/kg once daily by gavage for 4… vs Vehicle
Design
Preclinical, randomized
Follow-up
4 weeks
Authors
Discussion
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Member takes
Implication
Supports eNOS dependence of statin benefits in murine MI; leaves open human translation.
Structured PICO
Does atorvastatin improve survival and cardiac remodeling after myocardial infarction in an eNOS-dependent manner?
P
Population
Wild-type (WT) and eNO synthase (eNOS)-/- mice with extensive anterior myocardial infarction (n=117)
I
Intervention
Atorvastatin 50 mg/kg once daily by gavage for 4 weeks starting on day 1 after MI
C
Comparator
Vehicle
O
Outcome
Survival rate during 4 weeks after MIhard clinical
Statin-induced improvements in survival, LV function, and neovascularization after myocardial infarction are dependent on endothelial nitric oxide synthase.
Cite This Study
Landmesser et al. (2004) studied this question.